Ch.9 Patterns of Inheritance

WHAT WERE EXPERIMENTS MENDEL CONDUCT AND WHAT WERE HIS RESULTS?
Mendel conducted pea plant experiment. He crossed different plants and came out mostly with the same result, but some had different phenotypes. Je experimented with thousands of pea plants and recorded the phenotypic and genotypic traits of both using Punnet Squares. Mendel's finding showed that phenotypic traits in pea plants were inherited in discrete packages and at predictable frequencies. Mendel stated two laws, law of independent segregation, which states that a parent plant passed only one copy of a trait to the offspring. His second law was the Law of independent assortment that states that these traits met randomly in the offspring. 

WHY DO MORE MEN THAN WOMEN HAVE COLOR BLINDNESS?

Women have the sex chromosomes XX, while men have the chromosomes XY. The gene for normal color vision is found on the X-chromosome. If a woman has one X-chromosome with the gene and one without it, she will not be color blind. On the other hand, a man with an X-chromosome that is missing the gene has no backup. He will be color blind. Color blind women have both X-chromosomes missing the color vision gene. This has less probability than having just one X-chromosome missing the gene.

WHAT ARE THE MENDELIAN LAWS?
1) Law of segregation: pair of characteristics only one can be represented in a gamete. In another words,  for any pair of characteristics there is only one gene in a gamete even though there are two genes in ordinary cells.
2) Law of independent assortment: two characteristics the genes are inherited independently.
 If you had the genotype AaBb, you would make four kinds of gametes: they would contain the combinations of either AB, Ab, aB, or ab.

SUMMARY:
Genetic materials are only transported to offsprings. In another words, no matter how hard you work out to build your arm muscles, the offsprings will not get the muscle unless you have muscle cells that build muscles faster and easier than normally. In 1859, Mendel published a paper that says that the heritable factors retain their individuality generation after generation. He choose garden pea flower to study, using method that prevented fertilization, to cross fertilize the stamenless flower the carpel developed into a pod, and he planted. The seeds grew into offspring plants. Through these methods, Mendel was always sure of the parentage of new plants. He worked until he was sure he had true-breeding varieties. Mendel's law of segregation describes the inheritance of a single character. This starts with a cross between two parents and cross them to expect how offsprings are going to look like, using punnett square. We are able to describe phenotype and genotype of offsprings. Mendel's law of segregation states that pairs of alleles segregate during gamete formation. Homologous chromosomes state that alleles of a gene reside at the same locus on homologous chromosomes. Mendel's law of independent assortment states that each pair of alleles segregates independently of other pairs of alleles during gamete formation. From crossing P generations using punnett square, we are able to distinguish the percentage of phenotype and genotype of offsprings that will be born.
Genetic traits in humans can be tracked through family pedigrees. To analyze the pedigree, the geneticist applies logic and the Mendelian laws. Dominant traits are usually easier to occur, such as having freckles, widow's peak, and free earlobe. However people do have recessive traits, opposite of dominant traits, such as no freckles, straight hairline, and attached earlobe. Many inherited disorders in humans are controlled by a single gene. For example of recessive disorders, if both parents have gene of deaf, 25% of offsprings have possibilities to be deaf. The most common fatal genetic disease in the United states is cystic fibrosis. The CF allele is carried by about one in 25 people of European ancestry. The probability increases greatly if close relatives marry and have children. People with recent common ancestors are more likely to carry the same recessive relatives, called inbreeding, which is more like to produce offspring many types of inbred animals.
New technologies are able to provide insight into someone's genetic legacy. Genetic testing, fetal testing, fetal imaging, and ethical considerations are used. There is an incomplete phenotype. For example, if you cross red flower and white flower, there are probabilities of pink flower to be born between them.
Many genes have more than two alleles in the population. Most genes can be found in populations in more than two versions, known as multiple alleles. Although any particular individual carries, at most, two different alleles for a particular gene, in cases of multiple alleles, more than two possible alleles exist in the wider population. For example, blood group phenotype. There are four blood types, A, B, O, and AB. These letters refer to two carbohydrates, designated A and B, that may be found on the surface of red blood cells. Genotypes will be ii for O, IAIA or IAiA for A, IBIB or IBiB for B, and IAIB for AB. If I is a capital, it is a codominant; both alleles are expressed in heterozygous individuals.
Chromosome behavior accounts for Mendel's laws. The chromosome theory of inheritance was emerging. It states that genes occupy specific loci on chromosomes and it is the chromosomes that undergo segregation and independent assortment during meiosis. Thus, it is the behavior of chromosomes during meiosis and fertilization that accounts for inheritance patterns. Genes located close together on the same chromosome tend to be inherited together and they are called linked genes. They do not generally follow Mendel's law of independent assortment. Crossing over is very useful. They are used to produce new combinations of alleles, see the percentage of it, and also its data can be used to map genes.
Many animals have a pair of sex chromosomes, designated X and Y that determine and individual's sex. A gene located on either sex chromosome is called a sex-linked gene. By using punnett square, whether an individual is a male or a female is also able to be determined. Disorders can affect mostly males. For example, hemophilia, red-green color blindness, and duchenne muscular dystrophy.


KEY TERMS:
-self-fertilize: sperm-carrying pollen grains released from the stamens land on the egg containing carpel of the same flower.
-cross-fertilization: fertilization of one plant by pollen from a different plant.
-hybrids: the offspring of two different varieties
-P generation: the true-breeding parental plants
-F1 generation: true-breeding parental plants' hybrid offsprings
-F2 generation: offsprings of when F1 plants self-fertilizeor fertilize each other
-testcross: a mating between an individual of unknown genotype and a homozygous recessive individual
-phenotype: offsprings' composition, geneticists distinguish between an organism's expressed, or physical, traits
-genotype: genetic makeup such as PP, Pp, pp
-rule of addition: the probability that an event can occur in two or more alternative ways is the sum of the separate probabilities of the different ways.

This punnett square shows that both parents have gametes that can be showed as  RrYy cross over. And it shows the probabilities of offspring whether if it is going to have round yellow, round green, wrinkled yellow, or wrinkled green. In this punnett square, 1/16 have RRYY, RRyy, rrYY, or rryy, 2/16 have RRYy, rrYy, Rryy, or RrYY, and 4/16 have RrYy. This is genotype of offsprings. And 9/16 have round yellow, 3/16 have round green, or wrinkled yellow, and 1/16 have wrinkled green. It is phenotype of offsprings. 
http://www.youtube.com/watch?v=-2YPAt8hOmE

5FACTS:

1) Phenotype shows the physical looking of organism, and genotype shows the alleles.

2) Mendel's laws are valid for all sexually reproducing species, but genotype often does not dictate phenotype in the simple way his laws describe.

3) Sex chromosomes determine sex in many species. If a specie has Y, it is a male, and if it has XX, it is a female.

4) Genes are located on chromosomes, whose behavior during meiosis and fertilization accounts for inheritance patters.

5) Crossing over can separate linked alleles, producing gametes with recombinant chromosomes.